[Frontiers in Bioscience 11, 89-112, January 1, 2006] 89 HIV-1 inactivation by nucleic acid aptamers

1. Abstract 2. Nucleic acid aptamers 3. Inhibition of HIV-1 enzymatic function 3.1. Reverse Transcriptase. 3.1.1. Anti-RT drugs, side effects and resistance 3.1.2. RNA aptamers in vitro 3.1.3. Anti-RT ssDNA aptamers in vitro 3.1.4. Anti-RT RNA aptamers in cells 3.2. Protease 3.2.1. Protease aptamers 3.3. Integrase 3.3.1. Integrase aptamers in vitro 4. Inhibition of HIV-1 gene expression: transcriptional regulation and RNA transport 4.1 Rev 4.1.1. Rev aptamers in vitro 4.1.2. Non-aptamer Rev decoys in vivo 4.1.3. Rev aptamers in vivo 4.2. Tat 4.2.1. Tat aptamers in vitro 4.2.2. Tat aptamers and TAR decoys in vivo 4.3. TAR, RRE and other structured viral RNAs 5. Inhibition of viral packaging 5.1. Nucleocapsid and p55 polyprotein 5.1.1. NC and p55 aptamers in vitro 5.1.2. NC aptamers and decoys in vivo 6. Inhibition of viral entry 6.1. Glycoproteins gp120 and gp41 6.1.1. gp120 aptamers in vitro and in antiviral assay 7. Further considerations 8. References